Add to ORKGIntroduction: SPARC is a matricellular protein, which, along with other extracellular matrix components including collagens, is commonly over-expressed in fibrotic diseases. The purpose of this study was to examine whether inhibition of SPARC can regulate collagen expression in vitro and in vivo, and subsequently attenuate fibrotic stimulation by bleomycin in mouse skin and lungs. Methods: In in vitro studies, skin fibroblasts obtained from a Tgfbr1 knock-in mouse (TBR1CA; Cre-ER) were transfecte
Exposures to asbestos fibers by inhalation cause multiple asbestos-related diseases including asbest...
Objectives: Fibrosis is a predominant cause of death in systemic sclerosis (SSc). First epigenetic m...
sue from mice that do not express secreted protein acidic and rich in cysteine (SPARC) have reduced ...
INTRODUCTION: SPARC is a matricellular protein, which, along with other extracellular matrix compone...
Background: The genes of SPARC, CCR2, and SMAD3 are implicated in orchestrating inflammatory respons...
Abstract: Fibrosis is a common end-point of a number of different diseases such as hypertension, dia...
Failure of glaucoma filtration surgery (GFS) is commonly attributed to scarring at the surgical site...
Background: The current study utilized a Bleomycin-induced model of skin fibrosis to investigate the...
Fibrosis results from inflammatory tissue damage and impaired regeneration. In the context of bleomy...
This article is hosted on a website external to the CBCRA Open Access Archive. Selecting “View/Open...
Background: Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterised by ski...
BACKGROUND AND PURPOSE: Genetic deletion and pharmacological studies suggest a role for lysophosphat...
Background: To develop targeted antifibrotic therapy for glaucoma filtration surgery; this study det...
SPARC (osteonectin/BM40) is a secreted protein that modifies the interaction of cells with extracell...
OBJECTIVE: Reporter transgenes were introduced into the type 1 tight-skin (Tsk1/+) mouse model of sc...
Exposures to asbestos fibers by inhalation cause multiple asbestos-related diseases including asbest...
Objectives: Fibrosis is a predominant cause of death in systemic sclerosis (SSc). First epigenetic m...
sue from mice that do not express secreted protein acidic and rich in cysteine (SPARC) have reduced ...
INTRODUCTION: SPARC is a matricellular protein, which, along with other extracellular matrix compone...
Background: The genes of SPARC, CCR2, and SMAD3 are implicated in orchestrating inflammatory respons...
Abstract: Fibrosis is a common end-point of a number of different diseases such as hypertension, dia...
Failure of glaucoma filtration surgery (GFS) is commonly attributed to scarring at the surgical site...
Background: The current study utilized a Bleomycin-induced model of skin fibrosis to investigate the...
Fibrosis results from inflammatory tissue damage and impaired regeneration. In the context of bleomy...
This article is hosted on a website external to the CBCRA Open Access Archive. Selecting “View/Open...
Background: Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterised by ski...
BACKGROUND AND PURPOSE: Genetic deletion and pharmacological studies suggest a role for lysophosphat...
Background: To develop targeted antifibrotic therapy for glaucoma filtration surgery; this study det...
SPARC (osteonectin/BM40) is a secreted protein that modifies the interaction of cells with extracell...
OBJECTIVE: Reporter transgenes were introduced into the type 1 tight-skin (Tsk1/+) mouse model of sc...
Exposures to asbestos fibers by inhalation cause multiple asbestos-related diseases including asbest...
Objectives: Fibrosis is a predominant cause of death in systemic sclerosis (SSc). First epigenetic m...
sue from mice that do not express secreted protein acidic and rich in cysteine (SPARC) have reduced ...