Type 2 Diabetes Mellitus

Abstract: In recent years concepts are developing whether male hypogonadism and testosterone deficiency are the factors for developing insulin resistance and subsequent development of T2DM. This hypothesis developed from the observations that, testosterone deficiency in adult male is associated with T2DM, coronary artery disease and heart failure. Replacement of testosterone hormone to this subset of patients results in improvement of the condition. Recent studies have shown that male hypogonadism is more prevalent than thought earlier, is strongly associated with metabolic syndrome and may be a risk factor for the development of T2DM and coronary artery disease. Long-term studies are required to establish the relation with these diseases, the effect of testosterone replacement and its long-term safety profile with the exception of increase in haematocrit, which already we know. The prevalence of both hypogonadism and type 2 DM increases with age. But it is not proved beyond doubt, whether male hypogonadism contributes to the development of T2DM or T2DM leads to the development of hypogonadism or both are the presentations of some age related condition like increased fat mass. This concept, if it is supported by large multicentric studies, a new arena of understanding, treating and preventing diabetes mellitus in men will be opened