Meta-analysis: Ventilation Strategies and Outcomes of the Acute Respiratory Distress Syndrome and Acute Lung Injury

effect of different ventilatory strategies on the outcomes of patients with the acute respiratory distress syndrome (ARDS) and acute lung injury. Purpose: To determine whether ventilation with low tidal volume (VT) and limited airway pressure or higher positive end-expiratory pressure (PEEP) improves outcomes for patients with ARDS or acute lung injury. Data Sources: Multiple computerized databases (through March 2009), reference lists of identified articles, and queries of principal investigators. No language restrictions were applied. Study Selection: Randomized, controlled trials (RCTs) reporting mortality and comparing lower versus higher VT ventilation, lower versus higher PEEP, or a combination of both in adults with ARDS or acute lung injury. Data Extraction: Using a standard protocol, 2 reviewer teams as