Systematic review: bisphosphonates and osteonecrosis of the jaws. Ann Intern Med 2006;144(10):753–61

Osteonecrosis of the jaws is a recently described adverse side effect of bisphosphonate therapy. Patients with multiple myeloma and metastatic carcinoma to the skeleton who are receiving intra-venous, nitrogen-containing bisphosphonates are at greatest risk for osteonecrosis of the jaws; these patients represent 94 % of published cases. The mandible is more commonly affected than the maxilla (2:1 ratio), and 60 % of cases are preceded by a dental surgical procedure. Oversuppression of bone turnover is probably the primary mechanism for the development of this condition, although there may be contributing comorbid factors. All sites of potential jaw infection should be eliminated before bisphospho-nate therapy is initiated in these patients to reduce the necessity of subsequent dentoalveolar surgery. Conservative débridement of necrotic bone, pain control, infection management, use of antimi-crobial oral rinses, and withdrawal of bisphosphonates are pref-erable to aggressive surgical measures for treating this condition. The degree of risk for osteonecrosis in patients taking oral bisphosphonates, such as alendronate, for osteoporosis is uncer-tain and warrants careful monitoring. Ann Intern Med. 2006;144:753-761. www.annals.or