It was recently shown that Bcl-2-associated athanogene 1 (BAG1) is a potent neuroprotectant as well as a marker of neuronal differentiation. Since there appears to exist an equilibrium within the cell between BAG1 binding to heat shock protein 70 (Hsp70) and BAG1 binding to Raf-1 kinase, we hypothesized that changing BAG1 binding characteristics might significantly alter BAG1 function. To this end, we compared rat CSM14.1 cells and human SHSY-5Y cells stably overexpressing full-length BAG1 or a deletion mutant (BAGC) no longer capable of binding to Hsp70. Using a novel yellow fluorescent protein-based foldase biosensor, we demonstrated an upregulation of chaperone in situ activity in cells overexpressing full-length BAG1 but not in cells ov...
Aberrant alpha-synuclein aggregation is associated with the onset and progression of Parkinson’s dis...
Protein quality control involves molecular chaperones that recognize misfolded proteins thereby prev...
Deregulation of apoptosis is responsible for diseases that involve defects in the death pathway, suc...
Studies on the Hsp70 chaperone machine in eukaryotes have shown that Hsp70 and Hsp40/Hdj1 family pro...
BAG-1 is a multifunctional protein that blocks apoptosis and interacts with several types of protein...
Bag-1 Defizienz in Mäusen führt in der embryonalen Entwicklung zu einem lethalen Phänotyp mit schwer...
Bcl2-associated athanogene 3 (BAG3) protein belongs to the family of co-chaperones interacting with ...
Huntington´s disease, one of the so-called poly-glutamine diseases, is a dominantly inherited moveme...
BAG-1 (Bcl-2-associated athanogene-1) proteins interact with the HSC70 and HSP70 heat shock proteins...
BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets. There is ac...
Bcl2-associated athanogene 3 (BAG3) protein is a member of BAG family of co-chaperones that interact...
BAG-1 is multifunctional protein which interacts with a wide range of cellular targets to regulate g...
Heat shock cognate protein 70 (Hsc70) regulates protein homeostasis through its reversible interacti...
Aberrant alpha-synuclein aggregation is associated with the onset and progression of Parkinson’s dis...
Protein quality control involves molecular chaperones that recognize misfolded proteins thereby prev...
Deregulation of apoptosis is responsible for diseases that involve defects in the death pathway, suc...
Studies on the Hsp70 chaperone machine in eukaryotes have shown that Hsp70 and Hsp40/Hdj1 family pro...
BAG-1 is a multifunctional protein that blocks apoptosis and interacts with several types of protein...
Bag-1 Defizienz in Mäusen führt in der embryonalen Entwicklung zu einem lethalen Phänotyp mit schwer...
Bcl2-associated athanogene 3 (BAG3) protein belongs to the family of co-chaperones interacting with ...
Huntington´s disease, one of the so-called poly-glutamine diseases, is a dominantly inherited moveme...
BAG-1 (Bcl-2-associated athanogene-1) proteins interact with the HSC70 and HSP70 heat shock proteins...
BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets. There is ac...
Bcl2-associated athanogene 3 (BAG3) protein is a member of BAG family of co-chaperones that interact...
BAG-1 is multifunctional protein which interacts with a wide range of cellular targets to regulate g...
Heat shock cognate protein 70 (Hsc70) regulates protein homeostasis through its reversible interacti...
Aberrant alpha-synuclein aggregation is associated with the onset and progression of Parkinson’s dis...
Protein quality control involves molecular chaperones that recognize misfolded proteins thereby prev...
Deregulation of apoptosis is responsible for diseases that involve defects in the death pathway, suc...