Meta-analysis: Effect of Monotherapy and Combination Therapy with Inhibitors of the Renin–Angiotensin System on Proteinuria in Renal Disease

progression of chronic kidney disease. Reports suggest that angio-tensin-receptor blockers (ARBs) reduce proteinuria, but results are variable. The relative effect of ARBs and angiotensin-converting enzyme (ACE) inhibitors, and their combined administration, re-mains uncertain. Purpose: To establish the effect of ARBs versus placebo and alter-native treatments, and the effect of combined treatment with ARBs and ACE inhibitors, on proteinuria. Data Sources: English-language studies in MEDLINE and the Coch-rane Library Central Register of Controlled Trials (January 1990 to September 2006), reference lists, and expert contacts