Journal of Inorganic Biochemistry

ro sp and biological evaluation of their Sm and Ho complexes evaluate the effect of the macrocyclic cavity size and type of appended arms on their in vitro and in vivo behaviour. The radiolabelling efficiency was found to be higher than 98 % for all the complexes, except for those of tetp. All radiocomplexes studied are hydrophilic with To develop effective radiopharmaceuticals for therapy it is essential to choose the appropriate radionuclide and the carrier biomolecule to target selectively the disease site acteristics are attractive for therapeutic applications, as well as for imaging [7,8]. Complexes of 153Sm with ligands containing phospho-nate groups, such as QuadrametTM, are in clinical use for bone pain relief and treatment of bone metastasis, while 166Ho complexes with dotp and with dtpa are under clinica