Fijorek K: Inter-individual variability in the preclinical drug cardiotoxic safety assessment - analysis of the age - cardiomyocytes electric capacitance dependence

Abstract Electrical phenomena located within the plasma membrane of the mammalian cardiac cells are connected with the cells ’ main physiological functions—signals pro-cessing and contractility. They were extensively studied and described mathematically in so-called Hodgkin–Huxley par-adigm. One of the physiological parameters, namely cell electric capacitance, has not been analyzed in-depth. The aim of the study was to validate the mechanistic model describing the capacitive properties of cells, based on a collected experimental dataset which describes the electric capacitance of human ventricular myocytes. The gathered data was further utilized for developing an empirical corre-lation between a healthy individual’s age and cardiomyocyte electric capacitance