Original Research Article Study of Hormone Receptor Status of Breast Carcinoma and Its Correlation with the Established Prognostic Markers.

Context: Breast cancer is a complex disease with heterogeneous prognosis. The selection of systemic adjuvant chemotherapy is based on prognostic and predictive factors. The hormone receptor levels are good predictive markers of response to hormone therapy; but their prognostic value is still debated. Objective: The present study was undertaken to observe the trend and to analyze the status of hormone receptor expression in breast carcinoma at our institute, and to assess their value in terms of established prognostic markers, viz: tumor size, tumor grade, tumor necrosis, lymphovascular invasion, Cerb-B2 overexpression and lymph node metastasis status. Design: We analyzed 222 cases breast carcinomas reported at our institute from Jan 2002 to Dec 2010. Blocks of all cases were sent to Tata Memorial Hospital, Parel, Mumbai for Immunohistochemistry. Results: Majority (57.65%) of our patients belonged to age group 31 to 50 years. Only 40 % of the tumors were both ER and PR positive. The ER and PR receptor expression correlated well with tumor size, tumor grade, tumor necrosis and lymphovascular invasion, while it did no