Evaluation of Oxidative Stress and Antioxidant Status in Iron Deficiency Anemia

Anemia is a pathological condition in which there is a decrease in red blood cell mass or decrease amount of hemoglobin. Iron deficiency anemia (IDA) is the most common cause for it among all the others. IDA occurs when iron loss occurs and/or the dietary intake or absorption of iron is insufficient. Oxidative stress is an imbalance between free radicals and antioxidant molecules; an increase in oxidants and/or a decrease in antioxidant capacity which is one of the potential biochemical mechanisms involved in the pathogenesis of iron deficiency anemia. The aim of this study is to investigate oxidative stress and antioxidant status in patients with IDA. A total of 50 subjects (20 subjects with IDA and 30 healthy controls) were included in our study with the mean age of 32.38±13.74 years. Serum total antioxidant capacity, serum total peroxide level, oxidative stress index and iron indices {Hemoglobin, Mean Cell Volume (MCV), Mean Cell Hemoglobin Concentration (MCHC) were compared between the control and IDA subjects including serum total protein, albumin, uric acid and bilirubin. There were no significant differences between IDA subjects and controls with respect to age, gender and body mass index (BMI) Protein, Albumin, Uric acid and bilirubin in IDA subjects and controls were significantly higher in controls subjects than IDA.TP and OSI were significantly higher in IDA subjects than controls, whil