Add to ORKGPrimary cilia are sensory organelles that transmit extracellular signals into intracellular biochemical responses. Structural and functional defects in primary cilia are associated with a group of human diseases, known as ciliopathies, with phenotypes ranging from cystic kidney and obesity to blindness and mental retardation. Primary cilia mediate mechano- and chemosensation in many cell types. The mechanosensory function of the primary cilia requires the atypical G-protein-coupled receptor polycystin-1 and the calcium-permeable nonselective cation channel polycystin-2. Mechanical stimulations such as fluid-shear stress of the primary cilia initiate intracellular calcium rise, nitric oxide release, and protein modifications. In this review,...
Mechanosensation is crucial for cells to sense and respond to mechanical signals within their local ...
Primary cilia are microtubule-based organelles found in most mammalian cell types. Cilia act as sens...
Primary cilia are solitary nonmotile extensions of the centriole found on nearly all nucleated eukar...
Primary cilia are sensory organelles that transmit extracellular signals into intracellular biochemi...
Cilia are microscopic structures that extend from the surface of mammalian cells. Cilia can be categ...
Primary cilia, thin hair-like structures protruding from the apical surface of most mammalian cells,...
Over the past few decades, we have been able to integrate mechanobiology into the molecular basis of...
Primary cilia, thin hair-like structures protruding from the apical surface of most mammalian cells,...
Over the past decade, primary cilia have emerged as the premier means by which cells sense and trans...
Primary cilia are solitary, generally non-motile, hair-like protrusions that extend from the surface...
Fluid shear stress (FSS) is able to generate phenotypic changes in the cells in direct contact with ...
Dysfunction of many ciliary proteins has been linked to a list of diseases, from cystic kidney to ob...
Primary cilia (PC) are mechanical cell structures linked to the cytoskeleton and are central to how ...
Background— When challenged with extracellular fluid shear stress, vascular endothelial cells are kn...
The primary cilium is a mechanosensor in a variety of mammalian cell types, initiating and directing...
Mechanosensation is crucial for cells to sense and respond to mechanical signals within their local ...
Primary cilia are microtubule-based organelles found in most mammalian cell types. Cilia act as sens...
Primary cilia are solitary nonmotile extensions of the centriole found on nearly all nucleated eukar...
Primary cilia are sensory organelles that transmit extracellular signals into intracellular biochemi...
Cilia are microscopic structures that extend from the surface of mammalian cells. Cilia can be categ...
Primary cilia, thin hair-like structures protruding from the apical surface of most mammalian cells,...
Over the past few decades, we have been able to integrate mechanobiology into the molecular basis of...
Primary cilia, thin hair-like structures protruding from the apical surface of most mammalian cells,...
Over the past decade, primary cilia have emerged as the premier means by which cells sense and trans...
Primary cilia are solitary, generally non-motile, hair-like protrusions that extend from the surface...
Fluid shear stress (FSS) is able to generate phenotypic changes in the cells in direct contact with ...
Dysfunction of many ciliary proteins has been linked to a list of diseases, from cystic kidney to ob...
Primary cilia (PC) are mechanical cell structures linked to the cytoskeleton and are central to how ...
Background— When challenged with extracellular fluid shear stress, vascular endothelial cells are kn...
The primary cilium is a mechanosensor in a variety of mammalian cell types, initiating and directing...
Mechanosensation is crucial for cells to sense and respond to mechanical signals within their local ...
Primary cilia are microtubule-based organelles found in most mammalian cell types. Cilia act as sens...
Primary cilia are solitary nonmotile extensions of the centriole found on nearly all nucleated eukar...