Proposal applicable in the regulatory context of Plant Protection Products, Biocidial Products, and Chemicals targeted within REACH

1. The prompt for this work was the introduction into the new European Union Plant Protec-tion Products (PPP) Regulation (1107/2009) of an exclusion criterion for approval which ex-plicitly indicates that any active substance, safener and synergist with endocrine disrupting properties that may cause adverse effects in humans cannot be approved for marketing and use unless the exposure of humans under realistic proposed conditions of use is negligibl