COMMENTS AND RESPONSES Prevention of Diabetes With Mediterranean Diets TO THE EDITOR: We believe that Salas-Salvado ́ and colleagues ’ sub-

group analysis (1), which found that a Mediterranean diet enriched with extra-virgin olive oil reduces risk for diabetes, is methodologi-cally flawed. During the study, more participants were lost to follow-up in the low-fat diet control group (10.5%) than in the Mediterranean diet groups supplemented with olive oil (4.1%) or mixed nuts (6.9%). The authors state that participants in the control group “who withdrew had a worse cardiovascular risk profile at base-line than those who remained in the study. ” This fact indicates that the entire control group in the subgroup analysis had a potentially higher cardiovascular risk profile at baseline than the intervention groups. A higher cardiovascular risk profile at baseline in the control group could coexist with a higher likelihood of baseline prediabetes and hyperinsulinemia, particularly in women (2). Although the orig-inal trial stratified randomization by sex, the trial and the subgrou