REVIEW ARTICLE Corresponding author:

Out-of-hospital cardiac arrest claims 225,000 lives each year in the United States and a similar number in Europe, accounting for about half of all deaths due to cardiovas-cular disease (1). Even when resuscitation efforts are successful, recovery is too often limited by post-anoxic encephalopathy. The interest regarding hypothermic thera-py to protect brain after cardiac arrest start-ed in late ’50s of the past century and the first publication dates 1959 (2). In spite of promising evidences, mostly be-cause of the absence of simple and reliable cooling methods, apart from some farsee-ing and lonely voices as Peter Safar (3), th