Above State Bank of Mysore,

Abstract: Stress is known to affect synaptic plasticity; dendritic morphology and induces neurotoxic damage in humans, probably through generation of free radicals. In the present study, mice were selected and stress was induced using cyclophosphomide. For this it was given 1ml dose (40 mg/kg/day) for fifteen days. Another mouse was given anti-stress dose of quecertin (250mg/kg/day). It was treated with 1ml dose for thirteen days and on last two day it was given Cyclophosphamide to induce stress. A normal mouse was also kept in same condition as other two mice except that it was not stressed as was used as standard reference in the present study. At the end of one week the all the three mouse were sacrificed and liver was obtained for research. CYP is an alkylating agent which has as carrier a phosphorated ring. Cyclophosphamide has various toxic effects, which include alopecia, nausea, vomiting, leukopaenia and to a lesser degree thrombocytopenia, mucous ulcerations However quercetin is a flavanoids of family of phenolics compounds widely found in the cabbage, leek, and broccoli. It has got the free radical scavenging activity. Quercetin supplementation improves running time to fatigue by stimulating mitochondrial biogenesis in mice The Biochemical changes occurred in the mouse was observer b