EVALUATION OF PHYTOCHEMICAL AND BIOLOGICAL PROPERTIES ON STROBILANTHES

The present study was carried out to evaluate the phytochemical and biological properties of the plant of Stobilanthes ciliatus Nees. In this study, qualitative and quantitative determinations were conducted by different methods. The quantitative studies revealed the total percentage content of steroidal saponins, flavanoids, tannins and terpenoids in the leaves, stem and root respectively. Cytotoxic property of the plant extract was studied against human breast cancer (MCF-7) cell lines using thiazolyl blue dye exclusion technique (MTT assay). The extract showed moderate in vitro cytotoxic activity having IC 50 value of 3.68μg/ml. Analgesic property of the plant extract at a dose of 100 mg/kg & 200 mg/kg was evaluated against the standard drug Pentazocin at a dose of 5 mg/kg using tail clip models of pain. The extract of Stobilanthes ciliatus Nees showed more significant analgesic activity (p<0.001) as compared to standard drug. Key Words: Stobilanthes ciliatus Nees, Phytochemical studies, In vitro Cytotoxic study, In vivo Analgesic study, Tail clip method