©ARC Page | 126 Protective Activity of Moringa Oleifera Leaf Extract on Lindane Induced Testicular Damage in Rats

Abstract: Exposure of the body organs and systems to pesticides including lindane has found been to cause adverse effects, which affect functionality. Hence, this study was aimed at determining the ability, potency and nature of Moringa oleifera leaf in the protecting testis against lindane induced testicular damage based on some biochemical and histopathological parameters. Adult male rats were orally administered with lindane at a dose of 5.0mg/kg body weight per day for 30 days, the rat were killed using anesthetic ether, plasma was collected and testis were removed histopathological studies. Male albino rats were treated with lindane, decreased the fertilility hormone such as testosterone, LH, FSH and estradiol. Lindane alter fertility hormone and altered the biochemical parameter such as protein, cholesterol, lipid profile and histopathological disorganization. Administration of Moringa oleifera to lindane induced tooxiicty rats restored the altered parameters. Results showed that exposure to lindane testicular and concurrent administration of Moringa oleifera leaf extract possess the protective activity of lindane induced testicular toxicity in rats