Quantitative Angiographic Methods for Appropriate End-Point Analysis, Edge-Effect Evaluation, and Prediction of Recurrent Restenosis After Coronary Brachytherapy With Gamma Irradiation

OBJECTIVES The study was done to investigate the relationship between clinical restenosis and the relative angiographic location of the recurrent restenotic lesion, after treatment of in-stent restenosis with vascular brachytherapy in the Washington Radiation for In-Stent Restenosis Trial (WRIST). BACKGROUND Intracoronary radiation therapy reduces recurrence of in-stent restenosis. We investigated the above objective in patients enrolled in WRIST. METHODS The WRIST study randomized 130 patients to double-blinded therapy with gamma irradiation (iridium-192 [192Ir]) versus placebo after interventional treatment of diffuse in-stent restenosis. After the intervention and at follow-up, three vessel segments were individually analyzed with quantitative coronary angiography: 1) the “stent, ” 2) the “radiation ribbon, ” and 3) the “ribbonmargin ” segment (including 5 mm on either end of the injured or radiation-ribbon segment). Receiver operator curves (ROC) were used to assess the value of the follow-up percent diameter stenosis (DS) for each of the three analyzed segments in predicting target vessel revascularization (TVR). RESULTS 192Ir reduced recurrent restenosis (23.7 % vs. 60.7%, p 0.001) and the length of recurren