Aided Diagnosis of Dementia Type through Computer-Based Analysis of Spontaneous Speech

This pilot study evaluates the ability of machined learned algorithms to assist with the differential diagnosis of dementia subtypes based on brief (< 10 min) spontaneous speech samples. We ana-lyzed1recordings of a brief spontaneous speech sample from 48 participants from 5 different groups: 4 types of dementia plus healthy con-trols. Recordings were analyzed using a speech recognition system optimized for speaker-independent spontaneous speech. Lexical and acoustic features were automatically extracted. The resulting feature profiles were used as input to a machine learning system that was trained to identify the diagnosis assigned to each research participant. Between groups lexical and acoustic differences features were detected in accordance with expectations from prior research literature suggesting that classifications were based on fea-tures consistent with human-observed sympto-matology. Machine learning algorithms were able to identify participants ' diagnostic group with accuracy comparable to existing diagnostic methods in use today. Results suggest this clini-cal speech analytic approach offers promise as an additional, objective and easily obtained source of diagnostic information for clinicians.