Tuberculosis

To evaluate the adverse drug reactions (ADRs) induced by antitubercular drugs used in Directly Observed Treatment Short Course Plus (DOTS plus) from previously reported articles from referred sources. The occurrence rate of each type of ADR from entire ADRs were analyzed and compared. The total 2992 patients from 17 studies were analyzed. 2042 (68.24%) patients showed at least one type of adverse drug reaction. The majority of ADRs were related to nervous system, which were occurred in 2,013 (48.37%) patients. 1024 (25.52%) patients suffered with ADRs related to digestive system. Major ADRs were occurred related to GIT system such as liver disorders and hepatocellular injury etc. 502 (12.6%) patients showed ADRs related to sense organs. 134 (3.22%) patients showed ADRs such as insomnia, fatigue, headache, anemia, electrolyte disturbance and hypokalemia etc. Various types of adverse drug reactions related with different systems of body were observed in the study. ADRs were needed to be monitored during DOTS plus therapy. Correspondence to Author