RELATION BETWEEN WEIGHT, HEIGHT, GLYCEMIC STATUS AND PARASYMPATHETIC FUNCTIONS IN NONDIABETIC OFFSPRING OF TYPE 2 DIABETES

Objective: Diabetes Mellitus is group of common metabolic disorders that share the phenotype of hyperglycemia. Type 2 diabetes mellitus is a familial disease with a lifetime risk of 40 % if one parent has Type 2 diabetes. Over-weight is the second risk factor for type 2 diabetes mellitus. Till now, very few studies have shown early outcome of genetic transmission on cardiac autonomic activity among healthy offsprings with parental type 2 diabetes mellitus. Thus, the aim of this study was to examine the impact of parental Type 2 diabetes on autonomic nervous system and to determine whether autonomic neuropathy is present and its association with glycemic status, weight and height. Method: The cross-sectional study of Height, Weight, Glycemic status and Cardiovascular Autonomic Functions was carried out in 30 healthy offsprings of Type 2 Diabetic Parents (Study group) and 30 healthy offsprings of Nondiabetic Parents (Control group) in the age range of 18- 21 years. Results: There is insignificant decrease in parasympathetic functions and insignificant increase in Fasting and Post-load Blood Glucose in Study Group. There significant increase in weight, and height of subjects of Study Group. Conclusion: Our observations indicate that subclinical autonomic dysfunction may develop without the presence of long-term hyperglycemia in family members of type 2 diabetic subjects; Insulin resistance is a function of fat mass & because increasing body weight in the industrialized world has been accompanied by earlier presentation or accelera-tion of Type 2 Diabetes Mellitus. Different factors (including hyperglycemia) could subsequently affect the expres-sion of the genes and influence the progression of neuropathy