Assessment of the therapeutic role of Arabic Gum as Antioxidants on Cadmium induced kidney dysfunction in male albino rats

Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT: Many industrial emissions and the exhaust of vehicles contain heavy metals. Cadmium, (Cd) is one of these heavy metals and is emitted in the gas and dust remnants of some factories like copper smelters. Cadmium has a half-life of greater than ten years in human and thus accumulates in the body over the time. It is a potentially neurotoxic pollutant and approximately 50 % of the body burden of cadmium can be found in the kidney. Cadmium produces proximal tubule dysfunction and tissue injury. This injury may progress to a chronic interstitial nephritis. This study aimed to investigate the effect of Arabic gum on renal disorder induced by cadmium on male rats. The results obtained showed that daily intrapreitoneal injection of 2 mg cadmium chloride (CdCl2) / Kg b. wt / day for ten weeks induced renal toxicity in rats. Serum urea, creatinine, sodium (Na), potassium (K), phosphorus (P) and total calcium (Ca) were evaluated one and two weeks post-cadmium induction. Significant ameliorations were noted in these parameters after daily treatment with a dose 0.5 g/kg of Arabic gum during the experimental period