Guest Editorial / Misafir EditoryalDüşünen Adam The Journal of Psychiatry and Neurological Sciences 2014;27:181-185 DOI: 10.5350/DAJPN20142703001

Major depressive disorder with a prevalence of 8-16 % is one of the most common psychiatric diseases. Despite more than one hundred scientific papers were published about the etiology of depression every year, we have only a few well-described theories about its pathophysiology. One thing we sure about depression is, it has a strong genetic bases (1). However, we could not determine specific genes but have a number of candidate genes. The second most accepted theory about depression is about dysfunctional monoaminergic system mainly serotonergic system. This theory was supported evidences from preclinical animal and clinical serotonin depletion studies. However, the strongest evidences come from treatment options that we use to treat our patients, which are mainly consisted of serotonergic antidepressants. Th