Address for Correspondence Original Article Oxidative stress in liver disease patients

Aim: 1) To evaluate oxidative and antioxidant status in chronic liver disease. 2) To evaluate its inflammatory response in oxidative stress. Methods: Samples were collected from Wenlock District Government Hospital, Mangalore (25 patients with chronic liver disease, 25 normal patients) from Aug. 2007 to Aug. 2008. The Parameters estimated are in plasma (total thiols, total proteins, antioxidant activity, AOPP). In RBC suspension % hemolysis, in whole blood (GSH), in serum, serum iron. 1) Statistical analysis was done by Mann Whitney U test to determine the significant of difference between two means. 2)Informed and written consent was taken from patients and ethical committee clearance was obtained. Results: I. Non enzymatic antioxidants and TAA: · Whole blood glutathione (GSH) decreased · Plasma total thiols decreased · Albumin decreased II. Markers of oxidative damage: · AOPP increased · Percentage hemolysis no increase · Iron increased III. Plasma proteins as inflammatory markers: · Total proteins decrease · Globulin increased Conclusion: In our study the non-enzymatic antioxidant metabolites were found to be decreased in chronic liver disease. · There was very highly significant decrease blood GSH, plasma total thiols and albumin in chronic liver disease. · No significant increase in AOPP, % hemolysis. Very high significant increase in serum iron in patients of chronic liver disease. There is oxidative stress in patients of chronic liver disease