CASE REPORT | SMALL BOWEL Nearly Fatal Case of Whipple’s Disease in a Patient Mistakenly on Anti-TNF Therapy

Whipple’s disease is a rare cause of chronic diarrhea and abdominal pain that may be confused with inflam-matory bowel disease. We report a Whipple’s case misdiagnosed as Crohn’s disease in which treatment with anti-tumor necrosis factor (anti-TNF) therapy led to nearly fatal progression. Lymph node tissue obtained dur-ing laparotomy for suspected bowel necrosis stained dramatically with periodic acid–Schiff (PAS), and electron microscopy showed a bacterium consistent with Trophyrema whipplei. The patient made a remarkable recovery complicated only by cholestatic hepatitis, which was likely a treatment-associated inflammatory response. This case serves as a reminder that all granulomatous infections should be considered prior to initiation of anti-TNF therapies