Received

method validation Fast, economical, accurate, precise and reproducible RP–HPLC method was developed for the determination of Voglibose (VGB), Glimepiride (GLM) and Metformin HCl (MET). RP–HPLC method was developed on Jasco 2075 HPLC systems with Fine pack ODS C18 column (250mm) and using a mobile phase mixture containing mixed acetonitrile: phosphate buffer in the ratio of 85:15 (pH 4).The flow rate was 1 ml/min and the effluent was monitored at 223nm. The retention time of Voglibose, Glimepiride and Metformin HCl were 2.3, 3.8 and 5.1 min respectively. The method was validated in terms of linearity, precision, accuracy, specificity and system suitability parameters. The proposed method’s results were found to be satisfactory and are suitable for simultaneous determination of Voglibose, Glimepiride and Metformin HCl for routine quality control of drugs in bulk drug and formulation. Correspondence to Author