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Abstract: Building is meant to offer protection against harsh outdoor climate, provide both physiological and psychological comforts; healthy indoor environment for the occupants and to conserve energy. However, various residential building types in the traditional core area of Ogbomoso use different bio-climatic elements to address these functions thereby producing different degrees of comfort for the occupants. This paper examines bioclimatic performance of these residential building types with a view to determining the most efficient and sustainable one. In doing this, the study adopted Mahoney Table approach to climate analysis for the determination of design guidelines for comfort in the study area as various residential building typologies were compared using Mahoney recommendations. The indicator Table of Mahoney showed that the core area of Ogbomoso is too warm for comfort by days and in some nights. It also revealed that air movement is highly essential to reduce discomfort. The method produced some design recommendations which include good layout (East – West orientation) for exclusion of solar penetration. Spacing of buildings should be at least 5 times their height and sizes of openings should be between 40 – 80 % of north and south walls for effective ventilation in warm humid climate. However four residents building types wer