IBC 2013;5:5   •   DOI:  10.4051 / ibc.2013.5.2.0005www.ibc7.org 1 Interdisciplinary Bio Central SYNOPSIS Development of Information Biology (III)

Introduced were two biological investigations in which information biology played a sig-nificant role. In the first case independent findings in cancer research over a long period were united and organized by information biology and led to the outcome that was sub-ject to a Nobel Prize. The outcome has revealed that the cause of human cancer is locat-ed in the genome in a dormant condition. The second case shows how to elucidate the function of an unknown DNA sequence or ORF in prokaryotes by a large – scale comput-er homology search and analyses. For the elucidation the International DNA Databases and a large – scale computer were two key factors. Key Words: oncogene; proto-oncogene; PDGF; ORF; computer homology analysis Subject areas; Bioinformatics/Computational biology/Molecular modeling Author contribution; Y.T. wrote this article. *Correspondence and requests for materials should be addressed to Y.T