Available online: www.ijipsr.com November Issue 2765 SIMULTANEOUS ESTIMATION OF DESLORATIDINE AND MONTELUKAST IN COMBINED PHARMACEUTICAL DOSAGE FORM BY UV SPECTROSCOPY 1 Etta.Naveen Kumar*, 2

www.ijipsr.com A simple, accurate, precise and economical procedure for simultaneous estimation of Desloratidine and Montelukast in combined tablet dosage form has been developed utilizing concept of simultaneous equation method.The method is based upon determination of Desloratidine at 269nm and Montelukast at 283nm in methanol. Different analytical parameters such as linearity, precision, accuracy and ruggedness were determined according to ICH guidelines. Deslortidine and Montelukast at their respective wavelength shows linearity in the concentration range of 5-30 mcg/ml and 2-22mcg/ml.respectively.The method was validated statistically.The results of analysis formulation given as percentage of label claim were found to be 100.4 % and 101. % for Desloratidineand Montelukast respectively.Therefore, the proposed method can be used for the routine analysis of bothdrugs simultaneously in quality contro