Add to ORKGAbstract. NF-κB essential modulator (NEMO) is a kinase integral to the macrophage TNF-α pathway, which leads to the intracellular destruction of Mycobacteria species. Defects in the NEMO pathway result in spectrum of diseases, including but not limited to ectodermal dysplasia, Mendelian susceptibility to mycobacterial diseases, and incontinentia pigmenti. In addition, paucity of NEMO can lead to the inability to mount a proper immune response against opportunistic pyogenic and mycobacterial infections, leading to dissemination to various organ systems. This manuscript will discuss the numerous clinical manifestations of NEMO deficiency, the differential diagnosis of atypical mycobacterial infections in immunocompetent adults, and feature a ...
PubMed ID: 26167828It is well known that disseminated Mycobacterium bovis BCG infection is developed...
Nontuberculous mycobacteria (NTM) are categorized as one of the large and diverse groups of environm...
Germline mutations in five autosomal genes involved in interleukin (IL)-12-dependent, interferon (IF...
Background: An increasing number of rare genetic defects are associated with immunodeficiency and i...
Background: NF-κB1 is a master regulator of both acquired and innate responses. NFKB1 loss-of-functi...
Background: NF-κB1 is a master regulator of both acquired and innate responses. NFKB1 loss-of-functi...
Natural human immunity to the mycobacteria group, including Mycobacterium tuberculosis, Bacille Calm...
Natural human immunity to the mycobacteria group, including Mycobacterium tuberculosis, Bacille Calm...
Background: NF-κB1 is a master regulator of both acquired and innate responses. NFKB1 loss-of-functi...
NF-κB essential modulator (NEMO) deficiency causes ectodermal dysplasia with immunodeficiency in mal...
NF-kappa B essential modulator (NEMO, IKK-gamma) deficiency is a rare combined immunodeficiency caus...
WOS: 000238940500017PubMed ID: 16818673Germline mutations in five autosomal genes involved in interl...
We report here the first case of disseminated Mycobacterium xenopi infection in IL-12Rβ1 deficiency,...
Background: NF-κB1 is a master regulator of both acquired and innate responses. NFKB1 loss-of-functi...
X-linked osteopetrosis, anhydrotic ectodermal dysplasia, and immunodeficiency (XL-O-EDA-ID) is a dis...
PubMed ID: 26167828It is well known that disseminated Mycobacterium bovis BCG infection is developed...
Nontuberculous mycobacteria (NTM) are categorized as one of the large and diverse groups of environm...
Germline mutations in five autosomal genes involved in interleukin (IL)-12-dependent, interferon (IF...
Background: An increasing number of rare genetic defects are associated with immunodeficiency and i...
Background: NF-κB1 is a master regulator of both acquired and innate responses. NFKB1 loss-of-functi...
Background: NF-κB1 is a master regulator of both acquired and innate responses. NFKB1 loss-of-functi...
Natural human immunity to the mycobacteria group, including Mycobacterium tuberculosis, Bacille Calm...
Natural human immunity to the mycobacteria group, including Mycobacterium tuberculosis, Bacille Calm...
Background: NF-κB1 is a master regulator of both acquired and innate responses. NFKB1 loss-of-functi...
NF-κB essential modulator (NEMO) deficiency causes ectodermal dysplasia with immunodeficiency in mal...
NF-kappa B essential modulator (NEMO, IKK-gamma) deficiency is a rare combined immunodeficiency caus...
WOS: 000238940500017PubMed ID: 16818673Germline mutations in five autosomal genes involved in interl...
We report here the first case of disseminated Mycobacterium xenopi infection in IL-12Rβ1 deficiency,...
Background: NF-κB1 is a master regulator of both acquired and innate responses. NFKB1 loss-of-functi...
X-linked osteopetrosis, anhydrotic ectodermal dysplasia, and immunodeficiency (XL-O-EDA-ID) is a dis...
PubMed ID: 26167828It is well known that disseminated Mycobacterium bovis BCG infection is developed...
Nontuberculous mycobacteria (NTM) are categorized as one of the large and diverse groups of environm...
Germline mutations in five autosomal genes involved in interleukin (IL)-12-dependent, interferon (IF...