Available online: www.ijipsr.com November Issue 2792 DEVELOPMENT AND VALIDATION OF STANDARD ADDITION UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND FENOFIBRATE IN BULK AND PHARMACEUTICAL DOSAGE FORM

www.ijipsr.com A simple, rapid and specific UV spectroscopic method with good sensitivity was developed and validated for the simultaneous determination of Atorvastatin and Fenofibrate in bulk and pharmaceutical dosage form by standard addition method. In Methanol the λmax of Atorvastatin and Fenofibrate was fixed as 229 and 245 nm respectively using a Shimadzu UV-Visible spectrophotometer. In this proposed method both drugs obeyed linearity within the concentration range of 4-20 µg/ml and 4-20 µg/ml for Atorvastatin and Fenofibrate respectively. The low RSD values indicate good precision and high recovery values indicate accuracy of the proposed method. The proposed method has been applied to the determination of drugs in commercial formulations. Assay results were in good agreement with label claim. The method was validated as per ICH guidelines. The developed method was simple, accurate, precise, specific, sensitiv