For Whom do

Depression is a debilitating condition estimated to affect more than 151 millions people world-wide each year (WHO; World Health Organization, 2004), and antidepressant medications are the most common treatment for depressive symptoms. Indeed, the proportion of the U.S. population taking antidepressant med-ication nearly doubled between 1996 and 2005 (Olfson & Marcus, 2009), and antidepressant medications rank as the most commonly prescribed class of drugs in the U.S., according to most recent data reported by the Centers for Disease Control (National Center for Health Statistics, 2010). In the January 6, 2010 edition of the Journal of the American Medical Association, our research group published the results of a patient level meta-analysis in which we examined whether or not the efficacy of antidepressant medications depends on the severity of the depressive episode (Fournier et al., 2010). We initiated this study following the publicatio