© American Journal of Ethnomedicine Neuroprotective Activity of Crataeva nurvala Buch-Ham Stem Bark against Scopolamine- Induced Cognitive Impairment via Antioxidative Activities in Rats

Background: Crataeva nurvala Buch-Ham is a well explored traditional Indian medicinal plant, routinely used as folkloric medicine to treat various ailments in particular urolithiasis and neurodegenerative disorders associated with cognitive dysfunction. Objectives: The present study was undertaken with the objective to investigate the antioxidant and anti-dementia activities of Crataeva nurvala stem bark extract. Methods: The antioxidant and anti-dementia activities of Crataeva nurvala extract was carried out using superoxide dismutase (SOD), catalase (CAT) specific activities, total content of reduced glutathione (GSH), malondialdehyde (MDA) level (lipid peroxidation) and Hebb’s-William maze assays respectively in Wistar rats subjected to scopolamine (1 mg/kg i.p.) induced dementia. Results: Sub-acute exposures (daily, for 7 successive days) of Crataeva nurvala extract (100, 200 and 400 mg/kg) significantly increased antioxidant enzym