Formulation Development and Optimization of Intermediate Release Metoclopramide HCl Tablets by Central Composite Rotatable Design for IVIVC Studies

Abstract- The objective of this study was development and optimization of intermediate release formulation for IVIVC study of metoclopramide HCl. A four steps simple and cost effective study was performed. The first step was to study the micromeritic properties of different powder blends with and without metoclopramide HCl (Placebo). In second and third step, central composite design (CCRD) was used for intermediate release metoclopramide tablets. In the last step stability studies of three selected metoclopramide HCl tablet formulations which were calculated using R Gui software. Varying concentrations of excipients, HPMC K4M cps, Avicel PH-102, and lactose DC were used as variables in CCRD. Preformulation studies of two blended powders i.e. placebo and metoclopramide HCl were done to evaluate the angle of repose, loose bulk density, tapped bulk density, and compressibility index. Blending rate constant wa