Add to ORKGAims Stromal interaction molecule 1 (STIM1) has been shown to control a calcium (Ca2+) influx pathway that emerges during the hypertrophic remodelling of cardiomyocytes. Our aim was to determine the interaction of Orai1 and Orai3 with STIM1 and their role in the constitutive store-independent and the store-operated, STIM1-dependent, Ca2+ influx in cardiomyocytes. Methods and results We characterized the expression profile of Orai proteins and their interaction with STIM1 in both normal and hypertro-phied adult rat ventricular cardiomyocytes. Orai1 and 3 protein levels were unaltered during the hypertrophic process and both proteins co-immunoprecipitated with STIM1. The level of STIM1 and Orai1 were significantly greater in th
AbstractOrai1 subunits interacting with STIM1 molecules comprise the major components responsible fo...
ORAI1 is a protein located on the plasma membrane that acts as a calcium channel. Calcium enters via...
Store-operated calcium entry (SOCE), a fundamentally important homeostatic and Ca2+ signaling pathwa...
Aims Stromal interaction molecule 1 (STIM1) has been shown to control a calcium (Ca2+) influx pathwa...
Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of ne...
Disturbances in the regulation of cytosolic calcium (Ca(2+)) concentration play a key role in the va...
Abstract—Disturbances in the regulation of cytosolic calcium (Ca2) concentration play a key role in ...
AbstractStore-operated Ca2+ entry (SOCE) is an important mechanism of extracellular Ca2+ entry into ...
Two cellular proteins, stromal interaction molecule 1 (STIM1) and Orai1, are recently discovered ess...
Calcium flux through store-operated calcium entry is a central regulator of intracellular calcium si...
A drop of endoplasmic reticulum Ca(2+) concentration triggers its Ca(2+) ssensor protein stromal int...
Cellular homeostasis relies upon precise regulation of Ca2þ concentration. Stromal inter-action mole...
Increases in cytosolic Ca2+ concentration regulate diverse cellular activities and are usually evoke...
et al.Stromal interaction molecule 1 (STIM1) stimulates calcium ion (Ca2+) entry through plasma memb...
AbstractSTIM1 and ORAI1 constitute the core machinery of the ubiquitous store-operated calcium entry...
AbstractOrai1 subunits interacting with STIM1 molecules comprise the major components responsible fo...
ORAI1 is a protein located on the plasma membrane that acts as a calcium channel. Calcium enters via...
Store-operated calcium entry (SOCE), a fundamentally important homeostatic and Ca2+ signaling pathwa...
Aims Stromal interaction molecule 1 (STIM1) has been shown to control a calcium (Ca2+) influx pathwa...
Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of ne...
Disturbances in the regulation of cytosolic calcium (Ca(2+)) concentration play a key role in the va...
Abstract—Disturbances in the regulation of cytosolic calcium (Ca2) concentration play a key role in ...
AbstractStore-operated Ca2+ entry (SOCE) is an important mechanism of extracellular Ca2+ entry into ...
Two cellular proteins, stromal interaction molecule 1 (STIM1) and Orai1, are recently discovered ess...
Calcium flux through store-operated calcium entry is a central regulator of intracellular calcium si...
A drop of endoplasmic reticulum Ca(2+) concentration triggers its Ca(2+) ssensor protein stromal int...
Cellular homeostasis relies upon precise regulation of Ca2þ concentration. Stromal inter-action mole...
Increases in cytosolic Ca2+ concentration regulate diverse cellular activities and are usually evoke...
et al.Stromal interaction molecule 1 (STIM1) stimulates calcium ion (Ca2+) entry through plasma memb...
AbstractSTIM1 and ORAI1 constitute the core machinery of the ubiquitous store-operated calcium entry...
AbstractOrai1 subunits interacting with STIM1 molecules comprise the major components responsible fo...
ORAI1 is a protein located on the plasma membrane that acts as a calcium channel. Calcium enters via...
Store-operated calcium entry (SOCE), a fundamentally important homeostatic and Ca2+ signaling pathwa...