Synthesis, Characterization and Biological activities of Hydrazide Schiff’s Bases

A series of hydrazide Schiff’s bases were synthesized from different types of hydrazides and aldehydes, which were characterized through IR, LCMS, 1H and 13C NMR spectral studies. The synthesized pure compounds were screened for antibacterial and antioxidant activities. The S4 and S5 samples showed good antibacterial activity and maximum zone of inhibition of 18 mm and 12 mm against S. aureus and E. coli, respectively at 0.6 mg/disc concentration. S4 and S6 showed appreciable activity towards antioxidant DPPH and ABTS assay. Because of the biological activity of hydrazide Schiff’s bases, they became important in medicinal chemistry