American Journal of Phytomedicine and Clinical Therapeutics www.ajpct.org Original Article A Comparative Study on Antimicrobial Activity of Leaf Extract of Five Medicinal Plants and Commonly Used Antibiotics

Now a day, multidrug resistance of pathogenic microbes throws a challenge to scientists to discover the source of alternative medicine. This study focuses on the antimicrobial properties of the leaf extracts of five commonly known medicinal plants–Azadirachta indica, Alpine besseya, Mentha longifolia, Manilkara zapota, Bryophyllum pinnatum. The methanolic and ethanolic extracts of the leaf of the above mentioned plants were prepared by distillation method. Then comparative analysis of antimicrobial effects between those extracts and available antibiotics in the market were tested in Escherichia coli, Salmonella typhi and Pseudomonas sp. culture. All of the leaf extracts have shown potent antimicrobial activity and the extract of Bryophyllum pinnatum have shown the most potent activity compare to others