American Journal of Phytomedicine and Clinical Therapeutics www.ajpct.org Original Article Possible Combinational Effect of Silymarin with Hepatoprotective Plants in

Background: Silymarin, a flavonoid, has been reported to have hepatoprotective, antioxidative, anti-inflammatory and immunomodulatory activities. Picrorrhiza kurroa, Tephrosia purpurea, Asparagus racemosus and Phyllanthus amarus plants are well reported to possess anti-hepatotoxic ability. Objective: The present study was designed to investigate the effect of silymarin alone and in combination with the above mentioned hepatoprotective plants against experimentally induced liver injury. Materials and Methods: Wistar albino rats (180-220 g) of either sex (n=6) were employed in present study. Experimental hepatotoxicity was induced by the administration of paracetamol (3 g/kg, p.o.) or CCl4 (1 ml/kg, s.c.). Silymarin in the dose of 12.5, 25, 50 mg/kg, and silymarin 25 mg/kg in combination with plant extract: Picrorrhizakurroa, Tephrosiapurpurea, Phyllanthus amarus and Asparagus racemosu