Department of

It is evident from reported articles that bacterial infections often produce pain & inflammation. In normal practice, two groups of agents (chemotherapeutics & NSAID’s) are prescribed simultaneously. Unfortunately, none of the drugs available to possesses these activities in a single molecule. Therefore, our aim is to find a compound having dual effect of anti-inflammatory & antimicrobial activitiy (twin drug concept). Pyrazole and its derivatives have been reported for these dual activities. Here an attempt has been made to synthesize eight (4-substituted phenyl)[5-(4-substituted phenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]methanone derivatives. The synthesized derivatives were assessed for their in-vitro anti-microbial and anti-inflammatory activity. Chalcone derivative was synthesized by Claisen Schmidt condensation between acetophenone and substituted benzaldehyde. I