Review Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies

Abstract: We have analyzed host cell genes linked to HIV replication that were identified in nine genome-wide studies, including three independent siRNA screens. Overlaps among the siRNA screens were very modest (,7 % for any pairwise combination), and similarly, only modest overlaps were seen in pairwise comparisons with other types of genome-wide studies. Combining all genes from the genome-wide studies together with genes reported in the literature to affect HIV yields 2,410 protein-coding genes, or fully 9.5 % of all human genes (though of course some of these are false positive calls). Here we report an ‘‘encyclopedia’ ’ of all overlaps between studies (available a