Challenges of cancer genome sequencing and analysis

, RI 02912, USA Full list of author information is available at the end of the article the problem of distinguishing the relatively smallCancer is driven largely by somatic mutations that accu-mulate in the genome over an individual’s lifetime, with additional contributions from epigenetic and transcrip-tomic alterations. These somatic mutations range in scale from single-nucleotide variants (SNVs), insertions and deletions of a few to a few dozen nucleotide