13C-Sucrose Breath Test: Novel Use of a Noninvasive Biomarker of Environmental Gut Health WHAT’S KNOWN ON THIS SUBJECT: Australian Aboriginal

children have a high incidence of acute diarrheal disease and an underlying environmental enteropathy. WHAT THIS STUDY ADDS: In this study we used the application of a breath test to detect small intestinal integrity and health in Australian Aboriginal children living in remote communities of northern Australia. OBJECTIVE: Environmental enteropathy syndrome may compromise growth and predispose to infectious diseases in children in the devel-oping world, including Australian Aboriginal children from remote communities of the Northern Territory. In this study, we described the use of a biomarker 13C-sucrose breath test (SBT) to measure entero-cyte sucrase activity as a marker of small intestinal villus integrity and function. METHODS: This was a hospital-based prospective case-control stud