ORIGINAL ARTICLES Improved Delineation of Short Cortical Association Fibers and Gray/White Matter Boundary Using Whole-Brain Three-Dimensional Diffusion Tensor Imaging at Submillimeter Spatial Resolution

Recent emergence of human connectome imaging has led to a high demand on angular and spatial resolutions for diffusion magnetic resonance imaging (MRI). While there have been significant growths in high angular res-olution diffusion imaging, the improvement in spatial resolution is still limited due to a number of technical chal-lenges, such as the low signal-to-noise ratio and high motion artifacts. As a result, the benefit of a high spatial resolution in the whole-brain connectome imaging has not been fully evaluated in vivo. In this brief report, the impact of spatial resolution was assessed in a newly acquired whole-brain three-dimensional diffusion tensor im-aging data set with an isotropic spatial resolution of 0.85mm. It was found that the delineation of short cortical association fibers is drastically improved as well as the definition of fiber pathway endings into the gray/white matter boundary—both of which will help construct a more accurate structural map of the human brain connectome. Key words: brain; connectome; DTI; high resolution; short cortical association fiber