- Short communication Analgesic Activity of Mesua ferrea Linn.

English name-Cobra’s Saffron) belongs to the family Guttiferae.1 A number of biogenetically related constituents, viz., coumarins, xanthones, flavonoids, a few terpenoids and steroids have been isolated from various parts of the plant.1 Venom antidote property2 with plant extracts and antimicrobial3 activity of the whole flower extracts have been published. The antibacterial component 4-Alkyl- and 4-phynylcoumarins has been isolated from blossoms.4 The plant extensively grows in the hills and planted in gardens in many parts of the country.1 As a part of our continuing studies on the medicinal plants of Bangladesh the study was done to evaluate the analgesic activity using acetic acid induced writhing test in mice models. The plant leaf of Mesua ferrea (MF) was collected from Dhaka University campus during the month of April 2004 and taxonomically identified by the taxonomist of Dhaka University Herbarium. The pulverized coarse powder (250 gm) of the plant leaf was successively extracted by methanol (1 L). The extracts were filtered and concentrated with a rotary evaporator at low temperature (40- 50°C) and reduced pressure and was subsequently defatted5 to get the dried methanol (MF) extracts (28.22 g). The methanol extract was fractionated with n-hexane an