Models for Penicillium brevicompactum ATCC 16024 in Batch Bioreactor

Abstract: In the most cases of the practical fermentation processes with filamentous microorganisms, direct monitoring of the cell morphology and biomass distribution in the culture medium is not easily possible. Use of a mathematical model is a suitable way to describe the substrate uptake and cell growth behavior of these microorganisms. Penicillium brevicompactum is one of the morphologically complex filamentous fungi with different structural forms. In this work, nutrient uptake and cell growth kinetics were investigated using Monod and Moser models through batch submerged fermentation in a bench-scale stirred tank bioreactor. The experimental data were fitted with both the Monod and the Moser kinetic with a regression value of 0.87. The maximum specific growth rate and Monad's half-saturation coefficient were determined as 0.04 hG and 9 g. LG,1 1 respectively. In Moser case, the maximum specific growth rate and K were obtained as 0.06 hG and 6.8 g. LG,s 1 1 respectively. Thus, both Monod and Moser kinetic are considered to be partially applicable models to explain kinetics behavior of Penicillium brevicompactum in submerged batch bioreactor culture. Key words:Penicillium brevicompactum % Monod kinetic % Monod saturation constant % Moser kinetic % Specific growth rate % Submerged batch bioreactor INTRODUCTION The Penicillium species as well as Filamentous fungi are used for production of many filamentous fungi belonging to the most important know