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Abstract: We are describing a case of acute onset of amiodarone-related pulmonary toxicity (amiodarone lung) presented with clinical findings of acute ingravescent dyspnea, and reversed after prompt drug discontinuation. A concise review of the characteristics of pulmonary toxicity is also provided. Lung adverse effects may occur approximately in 5-17 % of treated patients, and are usually associated with older age, duration of the treatment, cumulative dosage, and probably previous co-existing lung disease may play a role. Such adverse pulmonary effects may occur either early (few days after starting treatment) or after several years, and onset of symptoms may be slowly insidious or acute, and dramatically pro-gressive. Thus, a high level of alertness is necessary in comorbid and elderly patients receiving amiodarone, even in an emergency setting, to consider this kind of adverse reaction among all possible differential diagnoses