Dependency structure matrix genetic algorithm (DSMGA), one of estimation of distribution algo-rithms (EDAs), adopts model-building mechanisms via dependency structure matrix clustering tech-niques. Previous researches have shown that DSMGA can effectively solve nearly decomposable prob-lems. DSMGA utilizes an entropy-based metric to detect the interactions among genes. The efficiency of DSMGA and other model-building GAs greatly depend on their interaction-detection metrics. This paper investigates several commonly used metrics, and proposes a new interaction-detection metric which aims at what GAs really need. The proposed metric, namely the differential mutual complement, is based on both the disruption and reproduction effects of the cro...
Abstract Synthetic genetic arrays have been very effective at measuring genetic interactions in yeas...
Most common diseases have a heritable component that is influenced by mutations on multiple loci, an...
Despite the emerging experimental techniques for perturbing multiple genes and measuring their quant...
In many different fields, researchers are often confronted by problems arising from complex systems....
Multi-variate estimation of distribution algorithms (EDAs) build models via detecting interactions b...
In this paper, we consider the problem of learning the genetic interaction map, i.e., the topology o...
Recent technological developments in genetic screening approaches have offered the means to start ex...
In many different fields, researchers are often confronted by problems arising from complex systems....
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Genetic interactions, especially negative genetic interactions, show the functional relationship bet...
Abstract Background It has now become clear that gene-gene interactions and gene-environment interac...
Gene-gene interactions may play an important role in the genetics of a complex disease. Detection an...
The goal of network clustering algorithms detect dense clusters in a network, and provide a first st...
Genetic algorithms (GAs) are multi-dimensional and stochastic search methods, involving complex in-t...
<div><p>Genome-wide analysis of gene-gene interactions has been recognized as a powerful avenue to i...
Abstract Synthetic genetic arrays have been very effective at measuring genetic interactions in yeas...
Most common diseases have a heritable component that is influenced by mutations on multiple loci, an...
Despite the emerging experimental techniques for perturbing multiple genes and measuring their quant...
In many different fields, researchers are often confronted by problems arising from complex systems....
Multi-variate estimation of distribution algorithms (EDAs) build models via detecting interactions b...
In this paper, we consider the problem of learning the genetic interaction map, i.e., the topology o...
Recent technological developments in genetic screening approaches have offered the means to start ex...
In many different fields, researchers are often confronted by problems arising from complex systems....
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Genetic interactions, especially negative genetic interactions, show the functional relationship bet...
Abstract Background It has now become clear that gene-gene interactions and gene-environment interac...
Gene-gene interactions may play an important role in the genetics of a complex disease. Detection an...
The goal of network clustering algorithms detect dense clusters in a network, and provide a first st...
Genetic algorithms (GAs) are multi-dimensional and stochastic search methods, involving complex in-t...
<div><p>Genome-wide analysis of gene-gene interactions has been recognized as a powerful avenue to i...
Abstract Synthetic genetic arrays have been very effective at measuring genetic interactions in yeas...
Most common diseases have a heritable component that is influenced by mutations on multiple loci, an...
Despite the emerging experimental techniques for perturbing multiple genes and measuring their quant...