Letter to the Editor Diagnostic Hematology Analysis of Acute Myeloid Leukemia in Korean Patients

Autosomal trisomy as a sole cytogenetic change has been de-scribed in several hematologic malignancy cases, but the num-ber of reports on the association between specific morphologies and individual structural cytogenetic abnormalities are few [1]. Trisomy 8 is the most common abnormality in myeloproliferative neoplasms (MPN), MDS, MDS/MPN and AML, and trisomy 4, 9, 11, 13, and 21 have been reported to be associated with my-eloid disorders [1, 2]. Here, we describe three patients with AML and show that trisomy 6 is the sole clonal cytogenetic bone marrow abnormality. The patients were adults without previous hematologic disorders, and were initially diagnosed with AML M1, M2, and M4, according to the French-American-British (FAB) classification. These patients received chemotherapy with or without allogenic peripheral blood stem cell transplantation (PBSCT), and showed variable clinical outcomes. The first case of sole trisomy 6 abnormality was reported in a patient with aplastic anemia (AA) [2]. The other reports showed that trisomy 6 was associated with hypoplastic bone marrow, dyserythropoiesis and AML prior to hypocellular marrow with MDS [3-5]. To establish a relationship between the clonality of AML and a single trisomy 6 abnormality, we searched PubMe