APPROVAL

We consider the problem of finding optimal orthogonal arrays for estimating main effects and some specified two-factor interactions. Based on theoretical results from Tang and Zhou (2009), we develop a computational algorithm for this purpose. The D-efficiency and bias are considered as the criteria for design optimality. The per-formance of the algorithm is evaluated by comparing the results obtained by the algorithm with those from complete search. Finally, we present a useful collection of optimal orthogonal arrays with small run sizes