THE EFFECT OF SPRINT TRAINING ON HUMAN SKELETAL MUSCLE PURINE NUCLEOTIDE METABOLISM

The effect of sprint training on human skeletal muscle purine nucleotide The major focus of this thesis was to examine the effect of sprint training on skeletal muscle purine nucleotide (PnN) metabolism. Specifically, this thesis studied the effects of sprint training on skeletal muscle PnN and metabolites of purine catabolism at rest, during a 30 s "all out " cycle bout and after 3 min of recovery. Furthermore, the accumulation of purine degradation prcxiucts in the plasma (ammonia, hypoxanthine) during exercise, and in recovery from a 30 s "all out " sprint was also examined. Finally, this thesis studied the influence of sprint training on performance variables pertinent to sprint exercise. Eight untrained subjects (six male and two female), performed a 30 s maximal sprint bout on a bicycle ergometer before and after a seven week intense sprint training regime. Venous blood was sampled at rest, after exercise and durin